Lysyl Oxidase Interacts with Hormone Placental Lactogen and Synergistically Promotes Breast Epthelial Cell Proliferation and Migration
نویسندگان
چکیده
LYSYL OXIDASE INTERACTS WITH HORMONE PLACENTAL LACTOGEN AND SYNERGISTICALLY PROMOTES BREAST EPTHELIAL CELL PROLIFERATION AND MIGRATION Noemi Polgar1, Ben Fogelgren1, 2, J. Michael Shipley3, Katalin Csiszar1 1 Cardiovascular Research Center, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA 96822 2 Department of Anatomy, Biochemistry and Physiology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA 96813 3 Washington University, Division of Pulmonary and Critical Care Medicine, St. Louis, MO USA 63110 Running title: Interaction of lysyl oxidase with placental lactogen Address correspondence to: Dr. Katalin Csiszar, Cardiovascular Research Center, John A. Burns School of Medicine, University of Hawaii, 1960 East-West Road Biomed T311, Honolulu, HI 96822. Tel: 808 956 9452; Fax: 808 956 9481; E-mail: [email protected]
منابع مشابه
Lysyl oxidase interacts with hormone placental lactogen and synergistically promotes breast epithelial cell proliferation and migration.
Lysyl oxidase (LOX), an extracellular amine oxidase, catalyzes the cross-linking of collagen and elastin. LOX has been also shown to play an essential role in promoting the invasive and metastatic potential of breast tumor cells. However, the LOX-interacting factors in these processes are not known. In this study, we identified placental lactogen (PL), a member of the growth hormone/prolactin h...
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